The podcast typically opens with a metafictional sketch involving Friedland and Mullen discussing the show and its production, including their feud with fictional producer Dracula (played by Mullen.) The sketch is followed by a monologue in which Friedland comments on recent events.
The monologue is followed by a conversation between Friedland and the guest.
Featured guests include astronomer and science communicator Neil deGrasse Tyson, businessman Dave Portnoy, musicians Mac DeMarco and Matty Healy, rapper Jadakiss, and journalist Chris Cuomo. Additionally, podcasters Will Menaker and Brace Belden, comedians Rick Glassman, Jordan Jensen, Brandon Wardell, and Chris Distefano, as well as Jackass star Steve-O and singer Matty Healy have appeared as guests on the weekly podcast.
This week, Adam and Nick are joined by stand-up comedian Ian Lara for an in-depth conversation that will keep laughing every step of the way.